Akka is using the Actors together with STM to create a unified runtime and programming model for scaling both UP (multi-core) and OUT (grid/cloud). Akka provides location transparency by abstracting away both these tangents of scalability by turning them into an ops task. This gives the Akka runtime freedom to do adaptive automatic load-balancing, cluster rebalancing, replication & partitioning
With systems such as Grid Engine, Condor and others, it is relatively easy these days for organizations to create robust distributed compute farms. See how the Grid::Request Perl module can make the authoring, submission and control of large distributed jobs easy and in a scheduler agnostic manner.